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1

Periodontal disease and type 2 diabetes mellitus: Is the HMGB1–RAGE axis the missing link?

Morimoto-Yamashita, Yoko, Ito, Takashi, Kawahara, Ko-ichi, Kikuchi, Kiyoshi, Tatsuyama-Nagayama, Shoko, Kawakami-Morizono, Yoshiko, Fijisawa, Mari, Miyashita, Keiko, Emoto, Makiko, Torii, Mitsuo, Toku

Journal:

Medical Hypotheses

Year:

2012

Language:

english

File:

PDF, 174 KB

english, 2012

2

Inhibition of HMGB1 by deep ocean water attenuates endotoxin-induced sepsis

Ko-ichi Kawahara, Teruto Hashiguchi, Takashi Ito, Kiyoshi Kikuchi, Yoko Morimoto, Toshiaki Shimizu, Yoko Oyama, Kazunori Takenouchi, Shin-ichiro Arimura, Noboru Taniguchi, Ikuro Maruyama, Masahiro Iwa

Journal:

Medical Hypotheses

Year:

2007

Language:

english

File:

PDF, 38 KB

english, 2007

3

High Mobility Group Box 1 Is Upregulated After Spinal Cord Injury and Is Associated With Neuronal Cell Apoptosis

Kawabata, Hideyuki, Setoguchi, Takao, Yone, Kazunori, Souda, Masakazu, Yoshida, Hiroki, Kawahara, Ko-ichi, Maruyama, Ikuro, Komiya, Setsuro

Journal:

Year:

2010

Language:

english

File:

PDF, 2.12 MB

english, 2010

4

Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-κB pathway inhibition

Yumiko Nakajima, Yasushi Furuichi, Kamal Krishna Biswas, Teruto Hashiguchi, Ko-ichi Kawahara, Kazuyo Yamaji, Tomonori Uchimura, Yuichi Izumi, Ikuro Maruyama

Journal:

Year:

2006

Language:

english

File:

PDF, 279 KB

english, 2006

5

E8002 Inhibits Peripheral Nerve Adhesion by Enhancing Fibrinolysis of l-Ascorbic Acid in a Rat Sciatic Nerve Model

Kikuchi, Kiyoshi, Setoyama, Kentaro, Takada, Seiya, Otsuka, Shotaro, Nakanishi, Kazuki, Norimatsu, Kosuke, Tani, Akira, Sakakima, Harutoshi, Kawahara, Ko-ichi, Hosokawa, Kazuya, Kiyama, Ryoji, Sumizon

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 2.48 MB

2020

6

Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis

Kamal Krishna Biswas, Krishna Pada Sarker, Kazuhiro Abeyama, Ko-ichi Kawahara, Satoshi Iino, Yasuharu Otsubo, Kazuhiko Saigo, Hiroyuki Izumi, Teruto Hashiguchi, Munekazu Yamakuchi, Kazuyo Yamaji, Ryuj

Journal:

Year:

2003

Language:

english

File:

PDF, 491 KB

english, 2003

7

TNFα induces acetylation of p53 but attenuates its transcriptional activation in rheumatoid synoviocytes

Nakazawa, Minako, Aratani, Satoko, Hatta, Mitsutoki, Araya, Natsumi, Daitoku, Hiroaki, Kawahara, Ko-Ichi, Watanabe, Shin-Ichi, Nakamura, Hiroshi, Yoshino, Shin-Ichi, Fujii, Ryouji, Fujita, Hidetoshi,

Journal:

International Journal of Molecular Medicine

Year:

2002

Language:

english

File:

PDF, 2.20 MB

english, 2002

8

Hydroxyapatite formed on/in agarose gel induces activation of blood coagulation and platelets aggregation

Shin-ichiro Arimura, Ko-ichi Kawahara, Kamal Krishna Biswas, Kazuhiro Abeyama, Masashi Tabata, Toru Shimoda, Daisuke Ogomi, Michiya Matsusaki, Shinya Kato, Takashi Ito, Kazumasa Sugihara, Mitsuru Akas

Journal:

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Year:

2007

Language:

english

File:

PDF, 204 KB

english, 2007

9

MK615, a Prunus mume Steb. Et Zucc (‘Ume’) Extract, Attenuates the Growth of A375 Melanoma Cells by Inhibiting the ERK1/2-Id-1 Pathway

Ko-ichi Tada, Ko-ichi Kawahara, Shigeto Matsushita, Teruto Hashiguchi, Ikuro Maruyama, Takuro Kanekura

Journal:

Phytotherapy Research

Year:

2012

Language:

english

File:

PDF, 234 KB

english, 2012

10

Edaravone: A new therapeutic approach for the treatment of acute stroke

Kiyoshi Kikuchi, Ko-ichi Kawahara, Naohisa Miyagi, Hisaaki Uchikado, Terukazu Kuramoto, Yoko Morimoto, Salunya Tancharoen, Naoki Miura, Kazunori Takenouchi, Yoko Oyama, Binita Shrestha, Fumiyo Matsuda

Journal:

Medical Hypotheses

Year:

2010

Language:

english

File:

PDF, 132 KB

english, 2010

11

Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review)

Kawahara, Ko-Ichi

Journal:

Experimental and Therapeutic Medicine

Year:

2011

Language:

english

File:

PDF, 302 KB

english, 2011

12

Post mortem contrast-enhanced computed tomography in a case of sudden death from acute pulmonary thromboembolism

KIKUCHI, KIYOSHI, KAWAHARA, KO-ICHI, TSUJI, CHIYOKO, TAJIMA, YUTAKA, KURAMOTO, TERUKAZU, SHIHARA, MIWAKO, KOGA, YUKARI, SHIOMI, NAOTO, UCHIKADO, HISAAKI, MORIMOTO, YOKO, MIURA, NAOKI, MERA, KENTARO, O

Journal:

Experimental and Therapeutic Medicine

Year:

2010

Language:

english

File:

PDF, 278 KB

english, 2010

13

1,5-Anhydro-d-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-κB p65 phosphorylation

Xiaojie Meng, Ko-ichi Kawahara, Yuko Nawa, Naoki Miura, Binita Shrestha, Salunya Tancharoen, Hisayo Sameshima, Teruto Hashiguchi, Ikuro Maruyama

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 382 KB

english, 2009

14

MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells

Yoko Morimoto, Kiyoshi Kikuchi, Takashi Ito, Masayuki Tokuda, Takashi Matsuyama, Satoshi Noma, Teruto Hashiguchi, Mitsuo Torii, Ikuro Maruyama, Ko-ichi Kawahara

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 373 KB

english, 2009

15

Involvement of the endocannabinoid system in periodontal healing

Sayaka Kozono, Takashi Matsuyama, Kamal Krishna Biwasa, Ko-ichi Kawahara, Yumiko Nakajima, Takehiko Yoshimoto, Yutaka Yonamine, Hideshi Kadomatsu, Salunya Tancharoen, Teruto Hashiguchi, Kazuyuki Noguc

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 427 KB

english, 2010

16

Valproic Acid Increases Susceptibility to Endotoxin Shock Through Enhanced Release of High-Mobility Group Box 1

Sugiura, Shinsuke, Ishihara, Yuichi, Komatsu, Toshinori, Hagiwara, Makoto, Tanigawa, Naomi, Kato, Yoshiko, Mizutani, Hiroki, Kawahara, Ko-ichi, Maruyama, Ikuro, Noguchi, Toshihide, Matsushita, Kenji

Journal:

Year:

2011

Language:

english

File:

PDF, 1014 KB

english, 2011

17

Cleavage of Host Cytokeratin-6 by Lysine-Specific Gingipain Induces Gingival Inflammation in Periodontitis Patients

Tancharoen, Salunya, Matsuyama, Takashi, Kawahara, Ko-ichi, Tanaka, Kenji, Lee, Lyang-Ja, Machigashira, Miho, Noguchi, Kazuyuki, Ito, Takashi, Imamura, Takahisa, Potempa, Jan, Kikuchi, Kiyoshi, Maruya

Journal:

Year:

2015

Language:

english

File:

PDF, 3.99 MB

english, 2015

18

Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis

Kikuchi, Kiyoshi, Setoyama, Kentaro, Kawahara, Ko-ichi, Nagasato, Tomoka, Terashi, Takuto, Ueda, Koki, Nakanishi, Kazuki, Otsuka, Shotaro, Miura, Naoki, Sameshima, Hisayo, Hosokawa, Kazuya, Harada, Yo

Journal:

Oxidative Medicine & Cellular Longevity

Year:

2017

Language:

english

File:

PDF, 4.00 MB

english, 2017

19

A natural therapeutic approach for the treatment of periodontitis by MK615

Morimoto-Yamashita, Yoko, Kawakami, Yoshiko, Tatsuyama, Syoko, Miyashita, Keiko, Emoto, Makiko, Kikuchi, Kiyoshi, Kawahara, Ko-ichi, Tokuda, Masayuki

Journal:

Medical Hypotheses

Year:

2015

Language:

english

File:

PDF, 288 KB

english, 2015

20

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

Nakahara, Mayumi, Ito, Takashi, Kawahara, Ko-ichi, Yamamoto, Mika, Nagasato, Tomoka, Shrestha, Binita, Yamada, Shingo, Miyauchi, Takahiro, Higuchi, Koji, Takenaka, Toshihiro, Yasuda, Tomotsugu, Matsun

Journal:

Year:

2013

Language:

english

File:

PDF, 2.47 MB

english, 2013

21

The expression of high mobility group box 1 (HMGB1) after acute cerebral infarction in rats

Matuda, Fumiyo, Kikuchi, Kiyoshi, Kawahara, Ko-ichi, Harutoshi,, Akakima,, Maruyama, Ikuro, Yoshida, Yoshihiro

Journal:

Neuroscience Research

Year:

2007

Language:

english

File:

PDF, 74 KB

english, 2007

22

HMGB1 Promotes the Development of Pulmonary Arterial Hypertension in Rats

Sadamura-Takenaka, Yukari, Ito, Takashi, Noma, Satoshi, Oyama, Yoko, Yamada, Shingo, Kawahara, Ko-ichi, Inoue, Hiromasa, Maruyama, Ikuro, West, James

Journal:

Year:

2014

Language:

english

File:

PDF, 4.89 MB

english, 2014

23

Diagnostic value of serum peptidome analyses for protease activated pathological conditions beyond cancer diagnosis

Teruto Hashiguchi, Kenji Tanaka, Lyang-Ja Lee, Ken Sasaki, Shoji Natsugoe, Ko-ichi Kawahara, Kimiyoshi Arimura, Ikuro Maruyama

Journal:

Medical Hypotheses

Year:

2009

Language:

english

File:

PDF, 532 KB

english, 2009

24

Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke

Kikuchi, Kiyoshi, Tancharoen, Salunya, Ito, Takashi, Morimoto-Yamashita, Yoko, Miura, Naoki, Kawahara, Ko-ichi, Maruyama, Ikuro, Murai, Yoshinaka, Tanaka, Eiichiro

Journal:

International Journal of Molecular Sciences

Year:

2013

Language:

english

File:

PDF, 285 KB

english, 2013

25

MK615: A new therapeutic approach for the treatment of oral disease

Yoko Morimoto-Yamashita, Miki Matsuo, Hitoshi Komatsuzawa, Ko-ichi Kawahara, Kiyoshi Kikuchi, Mitsuo Torii, Masayuki Tokuda

Journal:

Medical Hypotheses

Year:

2011

Language:

english

File:

PDF, 133 KB

english, 2011

26

Beyond neurological disease: New targets for edaravone (Review)

Kawahara, Ko-Ichi

Journal:

International Journal of Molecular Medicine

Year:

2011

Language:

english

File:

PDF, 306 KB

english, 2011

27

High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine

Noboru Taniguchi, Ko-Ichi Kawahara, Kazunori Yone, Teruto Hashiguchi, Munekazu Yamakuchi, Masamichi Goto, Keiichi Inoue, Shingo Yamada, Kosei Ijiri, Shunji Matsunaga, Toshihiro Nakajima, Setsuro Komiy

Journal:

Arthritis & Rheumatism

Year:

2003

Language:

english

File:

PDF, 341 KB

english, 2003

28

Hyper nuclear acetylation (HNA) in proliferation, differentiation and apoptosis

Ko-ichi Kawahara, Hisashi Kawabata, Satoko Aratani, Toshihiro Nakajima

Journal:

Ageing Research Reviews

Year:

2003

Language:

english

File:

PDF, 260 KB

english, 2003

29

Intraocular expression and release of high-mobility group box 1 protein in retinal detachment

Arimura, Noboru, Ki-i, Yuya, Hashiguchi, Teruto, Kawahara, Ko-ichi, Biswas, Kamal K, Nakamura, Makoto, Sonoda, Yasushi, Yamakiri, Keita, Okubo, Akiko, Sakamoto, Taiji

Journal:

Laboratory Investigation

Year:

2009

Language:

english

File:

PDF, 466 KB

english, 2009

30

Correction: Kikuchi, K., et al., Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke. Int. J. Mol. Sci. 2013, 14, 18899–18924.

Kikuchi, Kiyoshi, Tancharoen, Salunya, Ito, Takashi, Morimoto-Yamashita, Yoko, Miura, Naoki, Kawahara, Ko-ichi, Maruyama, Ikuro, Murai, Yoshinaka, Tanaka, Eiichiro

Journal:

International Journal of Molecular Sciences

Year:

2014

Language:

english

File:

PDF, 162 KB

english, 2014

31

Uric acid enhances alteplase-mediated thrombolysis as an antioxidant

Kikuchi, Kiyoshi, Setoyama, Kentaro, Tanaka, Eiichiro, Otsuka, Shotaro, Terashi, Takuto, Nakanishi, Kazuki, Takada, Seiya, Sakakima, Harutoshi, Ampawong, Sumate, Kawahara, Ko-ichi, Nagasato, Tomoka, H

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.66 MB

english, 2018

32

Attenuation of LPS-induced iNOS expression by 1,5-anhydro-d-fructose

Xiaojie Meng, Ko-ichi Kawahara, Kenji Matsushita, Yuko Nawa, Binita Shrestha, Kiyoshi Kikuchi, Hisayo Sameshima, Teruto Hashiguchi, Ikuro Maruyama

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 397 KB

english, 2009

33

Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells

Kiyoshi Kikuchi, Ko-ichi Kawahara, Kamal Krishna Biswas, Takashi Ito, Salunya Tancharoen, Yoko Morimoto, Fumiyo Matsuda, Yoko Oyama, Kazunori Takenouchi, Naoki Miura, Noboru Arimura, Yuko Nawa, Xiaoji

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 309 KB

english, 2009

34

Corrigendum to “Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-κB pathway inhibition” [FEBS Lett. 580 (2006) 613–619]

Yumiko Nakajima, Yasushi Furuichi, Kamal Krishna Biswas, Teruto Hashiguchi, Ko-ichi Kawahara, Kazuyo Yamaji, Tomonori Uchimura, Yuichi Izumi, Ikuro Maruyama

Journal:

Year:

2006

Language:

english

File:

PDF, 27 KB

english, 2006

35

Immunohistochemical expression of thrombomodulin in vestibular schwannoma

Hitoshi Yamahata, Shunji Yunoue, Hiroshi Tokimura, Ryosuke Hanaya, Hirofumi Hirano, Mai Tokudome, Prasanna Karki, Hajime Yonezawa, Sei Sugata, Ko-ichi Kawahara, Ikuro Maruyama, Kazunori Arita

Journal:

Brain Tumor Pathology

Year:

2013

Language:

english

File:

PDF, 807 KB

english, 2013

36

Corrigendum to: “Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt” [FEBS Letters 580 (2006) 703–710]

Kamal Krishna Biswas, Salunya Tancharoen, Krishna Pada Sarker, Ko-ichi Kawahara, Teruto Hashiguchi, Ikuro Maruyama

Journal:

Year:

2006

Language:

english

File:

PDF, 25 KB

english, 2006

37

New quinolones, ofloxacin and levofloxacin, inhibit telomerase activity in transitional cell carcinoma cell lines

Munekazu Yamakuchi, Masanori Nakata, Ko-ichi Kawahara, Isao Kitajima, Ikuro Maruyama

Journal:

Year:

1997

Language:

english

File:

PDF, 668 KB

english, 1997

38

Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction (Review)

Kawahara, Ko-ichi

Journal:

Experimental and Therapeutic Medicine

Year:

2011

Language:

english

File:

PDF, 218 KB

english, 2011

39

HMGB1 release in co-cultures of porcine endothelial and human T cells

Ko-ichi Kawahara, Kentaro Setoyama, Kiyoshi Kikuchi, Kamal Krishna Biswas, Ryozo Kamimura, Masahiro Iwata, Takashi Ito, Yoko Morimoto, Teruto Hashiguchi, Sonshin Takao, Ikuro Maruyama

Journal:

Xenotransplantation

Year:

2007

Language:

english

File:

PDF, 370 KB

english, 2007

40

ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB

Kentaro Mera, Ko-ichi Kawahara, Ko-ichi Tada, Kazuhiro Kawai, Teruto Hashiguchi, Ikuro Maruyama, Takuro Kanekura

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 586 KB

english, 2010

41

Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt

Kamal Krishna Biswas, Salunya Tancharon, Krishna Pada Sarker, Ko-ichi Kawahara, Teruto Hashiguchi, Ikuro Maruyama

Journal:

Year:

2006

Language:

english

File:

PDF, 366 KB

english, 2006

42

Imaging of intracellular translocation of protein kinase C

Kawahara, Shigenori, Kirino, Yutaka, Sakakibara, Manabu, Kudo, Yoshihisa, Takamura, Ko-Ichi, Inoue, Hiroko, Yoshioka, Tohru, Janoshazi, Agnes, de Barry, Jean, Olds, James L.

Journal:

Neuroscience Research Supplements

Year:

1994

Language:

english

File:

PDF, 141 KB

english, 1994

43

HMGB1 expression by activated vascular smooth muscle cells in advanced human atherosclerosis plaques

Katsumi Inoue, Ko-ichi Kawahara, Kamal Krishna Biswas, Kenji Ando, Kazuaki Mitsudo, Masakiyo Nobuyoshi, Ikuro Maruyama

Journal:

Cardiovascular Pathology

Year:

2007

Language:

english

File:

PDF, 603 KB

english, 2007

44

Hypernuclear Acetylation in Atherosclerotic Lesions and Activated Vascular Smooth Muscle Cells

Ko-ichi Kawahara, Shinichi Watanabe, Takayuki Ohshima, Yasuko Soejima, Takayuki Oishi, Satoko Aratani, Masanori Nakata, Masao Shibata, Katsumi Inoue, Tetsuya Amano, Ryouji Fujii, Kazuyuki Yanai, Masat

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 397 KB

english, 1999

45

C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells

Ko-ichi Kawahara, Kamal Krishna Biswas, Masako Unoshima, Takashi Ito, Kiyoshi Kikuchi, Yoko Morimoto, Masahiro Iwata, Salunya Tancharoen, Yoko Oyama, Kazunori Takenouchi, Yuko Nawa, Noboru Arimura, Me

Journal:

Cardiovascular Pathology

Year:

2008

Language:

english

File:

PDF, 573 KB

english, 2008

46

Saturated fatty acid palmitate induces extracellular release of histone H3: A possible mechanistic basis for high-fat diet-induced inflammation and thrombosis

Shrestha, Chandan, Ito, Takashi, Kawahara, Ko-ichi, Shrestha, Binita, Yamakuchi, Munekazu, Hashiguchi, Teruto, Maruyama, Ikuro

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

47

High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy

Oyama, Yoko, Hashiguchi, Teruto, Taniguchi, Noboru, Tancharoen, Salunya, Uchimura, Tomonori, Biswas, Kamal K, Kawahara, Ko-ichi, Nitanda, Takao, Umekita, Yoshihisa, Lotz, Martin

Journal:

Laboratory Investigation

Year:

2010

Language:

english

File:

PDF, 845 KB

english, 2010

48

The Debinding Method with Burying Process on the Metal Injection Molding.

Kouno, Takatoshi, Sasaki, Hideyuki, Kamada, Ko-ichi, Obara, Yasuji, Kawahara, Gyouzou

Journal:

Journal of the Japan Society of Powder and Powder Metallurgy

Year:

1991

File:

PDF, 2.87 MB

1991

49

Genetic diversity and genetic structure of Northern Goshawk (Accipiter gentilis) populations in eastern Japan and Central Asia

Yoshihide Takaki, Takayuki Kawahara, Hisashi Kitamura, Ko-ichi Endo, Takuma Kudo

Journal:

Conservation Genetics

Year:

2009

Language:

english

File:

PDF, 300 KB

english, 2009

50

Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model

Kikuchi, Kiyoshi, Setoyama, Kentaro, Terashi, Takuto, Sumizono, Megumi, Tancharoen, Salunya, Otsuka, Shotaro, Takada, Seiya, Nakanishi, Kazuki, Ueda, Koki, Sakakima, Harutoshi, Kawahara, Ko-ichi, Maru

Journal:

International Journal of Molecular Sciences

Year:

2018

Language:

english

File:

PDF, 3.16 MB

english, 2018

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